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Environmental toxicants : human exposures and their health effects / edited by Morton Lippmann.

Contributor(s): Material type: TextTextPublication details: New York : Wiley, 2000.Edition: 2nd edDescription: xvii, 987 p. : ill. ; 27 cmISBN:
  • 0471292982 (cloth : alk. paper)
Subject(s): DDC classification:
  • 616.9/8 21
LOC classification:
  • RA565 .E58 2000
Online resources:
Contents:
Machine generated contents note: 1 Introduction and Background -- Morton Lippmann, Ph.D. -- Characterization of Chemical Contaminants 2 -- Human Exposures and Dosimetry 7 -- Chemical Exposures and Dose-to-Target Tissues 7 -- Concentration of Toxic Chemicals in Human Microenvironments 8 -- Inhalation Exposures and Respiratory Tract Effects 11 -- Ingestion Exposures and GI Tract Effects 18 -- Skin Exposure and Dermal Effects 19 -- Absorption through Membranes and Systemic Circulation 20 -- Accumulation in Target Tissues and Dosimetric Models 21 -- Indirect Measures of Past Exposures 21 -- Characterization of Health 23 -- Exposure-Response Relationships 24 -- References 27 --2 Ambient Particulate Matter -- Morton Lippmann, Ph.D. -- Sources and Pathways for Human Exposure 32 -- Ambient Air PM Concentrations 36 -- Extent of Population Exposures to Ambient Air PM 38 -- Nature of the Evidence for Human Health Effects of Ambient Air PM 41 -- Epidemiological Evidence for Human Health Effects of Ambient Air PM -- Discussion and Current Knowledge on the Health Effects of PM 57 -- Standards and Exposure Guidelines 59 -- References 60 --3 Asbestos and Other Mineral and Vitreous Fibers -- Morton Lippmann, Ph.D. -- Important Special Properties of Fibers 65 -- Exposures to Fibers 68 -- Fiber Deposition in the Respiratory Tract 71 -- Fiber Retention, Dissolution, and Translocation 73 -- Properties of Mineral and Vitreous Fibers Relevant to Disease 81 -- Asbestos-Related Diseases 81 -- Review of Biological Effects of Size-Classified Fibers in Animals -- and Humans 83 -- Critical Fiber Parameters Affecting Disease Pathogenesis 86 -- Exposure-Response for Asbestos-Related Lung Cancer and Mesothelioma: -- Human Experience 95 -- Risk Assessment Issues: Asbestos 100 -- Review of Epidemiological Evidence for Health Effects in Workers -- Exposed to MMMFs 103 -- Risk Assessment Issues: Man-made Mineral Fibers 106 -- Key Factors Affecting Fiber Uptake and Toxicity: Recapitulation -- and Synthesis 108 -- Acronyms 109 -- References 110 --4 Benzene -- Bernard D. Goldstein, M.D., and Gisela Witz, Ph.D. -- Benzene Exposure 122 -- Uptake 124 -- Metabolism and Disposition 124 -- Mechanisms of Toxicity 131 -- Risk Assessment 138 -- References 141 --5 Carbon Monoxide -- Michael T Kleinman, Ph.D. -- CO Exposure and Dosimetry 151 -- Mechanisms of CO Toxicity 152 -- Populations at Risk of Health Effects due to CO Exposure 153 -- Regulatory Background 154 -- Health Effects of CO 155 -- Summary and Conclusions 165 -- References 166 --6 Chromium -- Mitchell D. Cohen, Ph.D., and Max Costa, Ph.D. -- Essentiality 173 -- Environmental Sources and Standards 174 -- Exposure Scenarios 176 -- Uptake and Distribution 178 -- Toxicological Effects 179 -- Immunotoxicity 180 -- Carcinogenicity and Teratogenic Effects 182 -- Genotoxicity and Mutagenicity 183 -- References 185 -- 7 Diesel Exhaust -- Joe L Mauderly, D.VM. -- Historical Overview 193 -- Exposures to Diesel Exhaust 194 -- Health Effects 199 -- Current Issues and Research Needs 230 -- References 232 --8 Dioxins and Dioxin-like Chemicals -- Michael J. De Vito, Ph.D., and Michael A. Gallo, Ph.D. -- Sources 243 -- Toxicological Effects and Mechanism of Action 249 -- Mechanism of Action 252 -- References 258 --9 Drinking Water Disinfection -- Richard J. Bull, Ph.D. -- Chemical Methods of Disinfection 268 -- Chemical Nature and Occurrence of Disinfectant By-products 269 -- Associations of Human Disease with Drinking Water Disinfection 276 -- Toxicology of Disinfectants 279 -- Summary and Conclusions 298 -- References 303 --10 Environmental Tobacco Smoke -- Jonathan M. Samet, M.D., M.S., and Sophia S. Wang, Ph.D. -- Exposure to Environmental Tobacco Smoke (ETS) 320 -- Health Effects of Involuntary Smoking in Children 331 -- Health Effects of Involuntary Smoking in Adults 345 -- Respiratory Symptoms and Illnesses in Adults 359 -- Summary 363 -- References 363 --11 Food Constituents, Additives, and Contaminants -- Joseph VRodricks, Ph.D. -- Food-Related Health Risks 377 -- Legal and Regulatory Framework 380 -- Toxicity Test Requirements and Safety Criteria 381 -- Substances Intentionally Added to Food 387 -- Food Contaminants of Industrial Origin 395 -- Constituents and Contaminants of Natural Origin 397 -- Summary and Conclusions 404 -- Acronyms 405 -- References 405.
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Holdings
Item type Current library Call number Copy number Status Date due Barcode Item holds
SES Book SES Book UOE Main Library Open shelf RA565 .E58 2000 (Browse shelf(Opens below)) 20067884 Available 20067884
Total holds: 0

Includes bibliographical references and index.

Machine generated contents note: 1 Introduction and Background -- Morton Lippmann, Ph.D. -- Characterization of Chemical Contaminants 2 -- Human Exposures and Dosimetry 7 -- Chemical Exposures and Dose-to-Target Tissues 7 -- Concentration of Toxic Chemicals in Human Microenvironments 8 -- Inhalation Exposures and Respiratory Tract Effects 11 -- Ingestion Exposures and GI Tract Effects 18 -- Skin Exposure and Dermal Effects 19 -- Absorption through Membranes and Systemic Circulation 20 -- Accumulation in Target Tissues and Dosimetric Models 21 -- Indirect Measures of Past Exposures 21 -- Characterization of Health 23 -- Exposure-Response Relationships 24 -- References 27 --2 Ambient Particulate Matter -- Morton Lippmann, Ph.D. -- Sources and Pathways for Human Exposure 32 -- Ambient Air PM Concentrations 36 -- Extent of Population Exposures to Ambient Air PM 38 -- Nature of the Evidence for Human Health Effects of Ambient Air PM 41 -- Epidemiological Evidence for Human Health Effects of Ambient Air PM -- Discussion and Current Knowledge on the Health Effects of PM 57 -- Standards and Exposure Guidelines 59 -- References 60 --3 Asbestos and Other Mineral and Vitreous Fibers -- Morton Lippmann, Ph.D. -- Important Special Properties of Fibers 65 -- Exposures to Fibers 68 -- Fiber Deposition in the Respiratory Tract 71 -- Fiber Retention, Dissolution, and Translocation 73 -- Properties of Mineral and Vitreous Fibers Relevant to Disease 81 -- Asbestos-Related Diseases 81 -- Review of Biological Effects of Size-Classified Fibers in Animals -- and Humans 83 -- Critical Fiber Parameters Affecting Disease Pathogenesis 86 -- Exposure-Response for Asbestos-Related Lung Cancer and Mesothelioma: -- Human Experience 95 -- Risk Assessment Issues: Asbestos 100 -- Review of Epidemiological Evidence for Health Effects in Workers -- Exposed to MMMFs 103 -- Risk Assessment Issues: Man-made Mineral Fibers 106 -- Key Factors Affecting Fiber Uptake and Toxicity: Recapitulation -- and Synthesis 108 -- Acronyms 109 -- References 110 --4 Benzene -- Bernard D. Goldstein, M.D., and Gisela Witz, Ph.D. -- Benzene Exposure 122 -- Uptake 124 -- Metabolism and Disposition 124 -- Mechanisms of Toxicity 131 -- Risk Assessment 138 -- References 141 --5 Carbon Monoxide -- Michael T Kleinman, Ph.D. -- CO Exposure and Dosimetry 151 -- Mechanisms of CO Toxicity 152 -- Populations at Risk of Health Effects due to CO Exposure 153 -- Regulatory Background 154 -- Health Effects of CO 155 -- Summary and Conclusions 165 -- References 166 --6 Chromium -- Mitchell D. Cohen, Ph.D., and Max Costa, Ph.D. -- Essentiality 173 -- Environmental Sources and Standards 174 -- Exposure Scenarios 176 -- Uptake and Distribution 178 -- Toxicological Effects 179 -- Immunotoxicity 180 -- Carcinogenicity and Teratogenic Effects 182 -- Genotoxicity and Mutagenicity 183 -- References 185 -- 7 Diesel Exhaust -- Joe L Mauderly, D.VM. -- Historical Overview 193 -- Exposures to Diesel Exhaust 194 -- Health Effects 199 -- Current Issues and Research Needs 230 -- References 232 --8 Dioxins and Dioxin-like Chemicals -- Michael J. De Vito, Ph.D., and Michael A. Gallo, Ph.D. -- Sources 243 -- Toxicological Effects and Mechanism of Action 249 -- Mechanism of Action 252 -- References 258 --9 Drinking Water Disinfection -- Richard J. Bull, Ph.D. -- Chemical Methods of Disinfection 268 -- Chemical Nature and Occurrence of Disinfectant By-products 269 -- Associations of Human Disease with Drinking Water Disinfection 276 -- Toxicology of Disinfectants 279 -- Summary and Conclusions 298 -- References 303 --10 Environmental Tobacco Smoke -- Jonathan M. Samet, M.D., M.S., and Sophia S. Wang, Ph.D. -- Exposure to Environmental Tobacco Smoke (ETS) 320 -- Health Effects of Involuntary Smoking in Children 331 -- Health Effects of Involuntary Smoking in Adults 345 -- Respiratory Symptoms and Illnesses in Adults 359 -- Summary 363 -- References 363 --11 Food Constituents, Additives, and Contaminants -- Joseph VRodricks, Ph.D. -- Food-Related Health Risks 377 -- Legal and Regulatory Framework 380 -- Toxicity Test Requirements and Safety Criteria 381 -- Substances Intentionally Added to Food 387 -- Food Contaminants of Industrial Origin 395 -- Constituents and Contaminants of Natural Origin 397 -- Summary and Conclusions 404 -- Acronyms 405 -- References 405.

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